Background: Given the minimal capacity and sometimes the failure of the mammalian
nervous system to regenerate and repair itself after damage, strategies are required to help enhance
this regenerative process. Adipose-derived Mesenchymal Stem Cells (ADMSCs) are likely candidates
to assist in the recovery process due to their ability to differentiate into neural cells. Successful
implementation of this intervention in a clinical setting would increase the rate of recovery following
traumatic brain injury.
Review: Various strategies have been attempted to differentiate ADMSCs into neural cells for clinical
use. Such methods have not been entirely successful in the development of functioning specialized
cells for subsequent practical use. Therefore, the implementations of this differentiation technique
in the clinical trial have not been effective. In this article, the potential of differentiating
ADMSCs into neural cells and the various methods employed, including biological induction,
chemical induction and photobiomodulation (PBM) will be discussed, where the combined use of
transducers and PBM for neural differentiation of ADMSCs is also deliberated.
Conclusion: PBM shows promise as an avenue for effective ADMSCs differentiation into neural
cells and their proliferation. Applying PBM with optimized biological factors and chemical inducers
may prove to be an effective tool for clinical application.