Background: A series of β-diketone hydrazones have been synthesized via condensation
of isoniazid with series of β-diketone. The structures of the Schiff bases are established by elemental
and spectroscopic techniques. The prepared compounds were screened for antibacterial and
antioxidant potential by DPPH free-radical scavenging activity and Ferric reducing antioxidant
power (FRAP) assays.
Methods: β-diketone hydrazine derivatives were synthesized by simple condensation between various
β-diketones and isoniazid. The titled compounds were synthesized following both conventional
and microwave irradiation methods. The in vitro antibacterial activity of synthesized derivatives
was evaluated against gram-positive (B. subtilis, S. aureus and S. pyogenes) and gram-negative (E.
coli, and K. pneumonia) bacterial strains and expressed in terms of zone of inhibition and also
screened for antioxidant activity.
Results: The yield of products was appreciably increased in shorter reaction times with the aid of
microwave-assisted synthesis. Therefore, it follows the green chemistry approach by making the
above reactions eco-friendly. The synthesized compounds were characterized using FT-IR, 1H
NMR, 13C NMR, and elemental analysis techniques. The spectroscopic techniques showed the formation
of β-diketone hydrazone compounds. Theoretical data show good agreement with the experimental
results. Some of the compounds displayed significant antibacterial and antioxidant potentials
when compared to the standard drug.
Conclusion: In the present research work, we report the synthesis of some novel β-diketone hydrazone
derivatives. A high yield of compounds was noted under microwave-assisted reaction in shorter
reaction times. The results revealed that the synthesized Schiff bases showed good radical scavenging