Regulation of Electrolyte Permeability by Herbal Monomers in Edematous Disorders

Author(s): Yong Cui, Yapeng Hou, Honglei Zhang, Yanhong Liu, Kejun Mao, Hongguang Nie, Yan Ding*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 6 , 2021

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Edema is a gradual accumulation of fluid in the interstitial tissues or luminal cavities, which is regulated by ion transport pathways and reflects dysfunction of fluid and salt homeostasis. Increasing evidence suggests that some herbal monomers significantly reduce organ/tissue edema. In this review, we briefly summarized the electrolyte permeability involved in pathomechanisms of organ edema, and the benefits of herbal monomers on ionic transport machinery, including Na+-K+-ATPase, Na+ and Cl- channels, Na+-K+-2Cl- co-transporter, etc. Pharmaceutical relevance is implicated in developing advanced strategies to mitigate edematous disorders. In conclusion, the natural herbal monomers regulate electrolyte permeability in many edematous disorders, and further basic and clinical studies are needed.

Keywords: Herbal monomers, edema, ion channels, electrolyte permeability, epithelium, ionic transport machinery.

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Article Details

Year: 2021
Published on: 17 September, 2020
Page: [833 - 839]
Pages: 7
DOI: 10.2174/1381612826666200917144655
Price: $65

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