Edema is a gradual accumulation of fluid in the interstitial tissues or luminal cavities, which is regulated
by ion transport pathways and reflects dysfunction of fluid and salt homeostasis. Increasing evidence
suggests that some herbal monomers significantly reduce organ/tissue edema. In this review, we briefly summarized
the electrolyte permeability involved in pathomechanisms of organ edema, and the benefits of herbal
monomers on ionic transport machinery, including Na+-K+-ATPase, Na+ and Cl- channels, Na+-K+-2Cl- co-transporter,
etc. Pharmaceutical relevance is implicated in developing advanced strategies to mitigate edematous disorders.
In conclusion, the natural herbal monomers regulate electrolyte permeability in many edematous disorders,
and further basic and clinical studies are needed.