Improved Drug Delivery System for Cancer Treatment by D-Glucose Conjugation with Eugenol From Natural Product

Author(s): Mas Amira Idayu Abdul Razak, Haslinda Abdul Hamid, Raja Nor Izawati Raja Othman, Shaik Alaudeen Mohd Moktar, Azizi Miskon*

Journal Name: Current Drug Delivery

Volume 18 , Issue 3 , 2021

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Graphical Abstract:


Introduction: Bioconjugations are swiftly progressing and are being applied to solve several limitations of conventional Drug Delivery Systems (DDS) such as lack of water solubility, non-specific, and poor bioavailability. The main goals of DDS are to achieve greater drug effectiveness and minimize toxicity to the healthy tissues.

Objectives and Methods: In this study, D-glucose was conjugated with eugenol to target the cancer cells. To identify the implication of the anticancer effect, osteosarcoma (K7M2) cells were cultured and the anti-proliferative effect was performed using MTT [3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide assay] test in order to evaluate the viability and toxicity on cells with various concentrations of eugenol and D-glucose-eugenol conjugate in 24-hour incubation.

Results: It was found that, the successful confirmation of the conjugation between D-glucose and eugenol was obtained by 1H NMR spectroscopy. MTT assay showed inhibitory concentration (IC50 value) of D-glucose-eugenol was at 96.2 μg/ml and the decreased of osteosarcoma cell survival was 48%.

Conclucion: These findings strongly indicate that K7M2 cells would be affected by toxicity of Dglucose- eugenol. Therefore, the present study suggests that D-glucose-eugenol has high potential to act as an anti-proliferative agent who may promise a new modality or approach as the drug delivery treatment for cancer or chemotherapeutic agent.

Keywords: Conjugation, D-glucose, eugenol, Drug Delivery Systems (DDS), cancer treatment, osteosarcoma (K7M2).

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Article Details

Year: 2021
Published on: 17 May, 2021
Page: [312 - 322]
Pages: 11
DOI: 10.2174/1567201817666200917123639
Price: $65

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