Title:The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke
VOLUME: 18 ISSUE: 12
Author(s):Li Gao, Zhenghong Song, Jianhua Mi, Pinpin Hou, Chong Xie, Jianquan Shi, Yansheng Li* and Anatol Manaenko*
Affiliation:Department of Neurology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, Department of Neurology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, Department of Neurology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, Central Laboratory, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, Departmeng of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, Departmeng of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Department of Neurology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201112, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016
Keywords:Ischemic stroke, stem cells, blood-brain barrier, tissue plasminogen activator, neurogenesis.
Abstract:Ischemic stroke is one of the main causes of mortality and disability worldwide. However,
efficient therapeutic strategies are still lacking. Stem/progenitor cell-based therapy, with its vigorous
advantages, has emerged as a promising tool for the treatment of ischemic stroke. The mechanisms
involve new neural cells and neuronal circuitry formation, antioxidation, inflammation alleviation,
angiogenesis, and neurogenesis promotion. In the past decades, in-depth studies have
suggested that cell therapy could promote vascular stabilization and decrease blood-brain barrier
(BBB) leakage after ischemic stroke. However, the effects and underlying mechanisms on BBB integrity
induced by the engrafted cells in ischemic stroke have not been reviewed yet. Herein, we
will update the progress in research on the effects of cell therapy on BBB integrity after ischemic
stroke and review the underlying mechanisms. First, we will present an overview of BBB dysfunction
under the ischemic condition and cells engraftment for ischemic treatment. Then, we will summarize
and discuss the current knowledge about the effects and underlying mechanisms of cell therapy
on BBB integrity after ischemic stroke. In particular, we will review the most recent studies in
regard to the relationship between cell therapy and BBB in tissue plasminogen activator (t-PA)-mediated
therapy and diabetic stroke.
