A Review on Mechanistic and Pharmacological Findings of Diabetic Peripheral Neuropathy including Pharmacotherapy

Author(s): Ruchi Tiwari*, Pranay Wal, Priya Singh, Gaurav Tiwari, Awani Rai

Journal Name: Current Diabetes Reviews

Volume 17 , Issue 3 , 2021


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Abstract:

Background: Chronic hyperglycemia and related complications involving peripheral nerves in diabetes are one of the most severe microvascular complications with an average prevalence of 50–60%. Diabetic neuropathy is among the vascular disorders of diabetes, the most debilitating and crippled, lethal condition impacting patients’s quality of life.

Methods: In the present review article, several hypotheses associated with the pathogenesis of Diabetic Peripheral Neuropathy (DPN) have been introduced, among them metabolic pathways associated with polyol pathway, oxidative stress, production of reactive oxygen species (ROS) amplified under chronic hyperglycemic conditions and activation of transcription factor Nuclear factor-κB (NF- κB). The review article also possesses pathogenetic and pharmacologic treatments along with others, including acupressure, lidocaine, and capsaicin for DPN.

Conclusion: It may be concluded that we can combat the pathogenesis of DPN with different suggested treatments.

Keywords: Diabetic peripheral neuropathy, pathogenesis of DPN, available treatments, pathogenetic treatments, symptomatic treatments, herbal treatments, supporting literatures.

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2021
Published on: 14 September, 2020
Page: [247 - 258]
Pages: 12
DOI: 10.2174/1573399816666200914141558
Price: $65

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