Login Register Cart 0
Generic placeholder image

Drug Delivery Letters

Editor-in-Chief

ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris

Author(s): Rupali Singh and Rishabha Malviya*

Volume 11, Issue 1, 2021

Published on: 10 September, 2020

Page: [44 - 51] Pages: 8

DOI: 10.2174/2210303110999200910103909

Price: $65

Abstract

Background: The chronotherapy concept attains considerable focus towards itself due to its pulsatile fashion rather than continuous delivery. The delivery of the right amount of drug to the target organ at the most appropriate time is fulfilled by using the chronotherapeutic dosage form.

Aim: The present study aims to develop and evaluate a chronotherapeutic drug delivery system by using natural polymer for time-specific drug delivery at the target site.

Methods: Tamarind seed polysaccharide was extracted and used in the preparation of core tablets. Nine formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on a 6 mm punch. The core tablets were prepared by using the compression coating method. The three batches F1, F2, and F3 were prepared by using tamarind gum in different concentrations i.e., 45%, 22.5%,and 67.5%, respectively, and compressed at 8 tonnes of pressure on 12 mm of punch. The finally compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl alcohol was used as a solvent. In a controlled medium, a stability study was performed to evaluate the physical appearance, drug content, and release of the prepared core tablet.

Result and Discussion: All the nine formulations of tablets were prepared successfully and the evaluation studies (thickness, weight variation, hardness, friability, etc.) revealed that all the formulations were within the official range. The release study of the drug revealed that the formulation F7 containing 67.5% of tamarind polymer, coated with 2%, 4%, and 5% of ethylcellulose solution released 59.68 ± 1.03% (Q50%) drug within 5 h whereas 87.09 ± 2.08% (Q80%) within 6 h and 97.74 ± 2.19% of the drug was released within 12 h. The formulation F7 was found to be more effective as it released the maximum amount of drug in a short period as compared to other formulations.

Conclusion: The coating of core tablets allowed to prepare pharmaceutical dosage form for timespecific drug delivery. These chronotherapeutic core tablets can be used for the treatment of angina pectoris and hypertension, etc.

Keywords: Chronotherapy, compression coated tablet, enteric coated tablet, unit dosage form, drug delivery, formulation optimization.

« Previous Next »
Graphical Abstract

[1]
Lu, D.; Zhao, M.; Chen, M.; Wu, B. Circadian clock–controlled drug metabolism: Implications for chronotherapeutics. Drug Metab. Dispos., 2020, 48(5), 395-406.
[http://dx.doi.org/10.1124/dmd.120.090472] [PMID: 32114506]
[2]
Sunil, S.A.; Srikanth, M.V.; Rao, N.S.; Murthy, K.V.R. Chronotherapeutic drug delivery from indomethacin compression coated tablets for early morning pain associated rheumatoid arthritis. Curr. Drug Deliv., 2013, 10(1), 109-121.
[http://dx.doi.org/10.2174/1567201811310010017] [PMID: 22974284]
[3]
Tung, N.T.; Nguyen, C.H.; Nguyen, V.D.; Nguyen, V.L.; Tran, C.S. Formulation and in vivo imaging evaluation of colonic targeting tablets prepared by a simple dry powder coating technique. J. Pharm. Investig., 2019, 1-16.
[http://dx.doi.org/10.1007/s40005-019-00463-x]
[4]
Battu, V.; Priya, S.P. Formulation and evaluation of extended release matrix tablets of metoprolol succinate using natural polymers. Int. J. Health Sci. Res., 2019, 9(4), 233-241.
[5]
Okafo, S.E.; Avbunudiogba, J.A.; Ejomafuvwe, E. Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using Brachystegia eurycoma gum. J. Pharm. Bioresour., 2020, 17(1), 34-43.
[http://dx.doi.org/10.4314/jpb.v17i1.7]
[6]
Srivastava, P.; Malviya, R. Extraction, characterization & evaluation of orange peel waste derived pectin as a pharmaceutical excipient. J. Nat. Prod., 2011, 1, 1-6.
[7]
Madhulika, G.S.S.V.; Kuber, B.R. A review on natural and synthetic polymers employed in the formulation of oral disintegrating tablets. J. Drug Deliv. Ther., 2019, 9(2-s), 652-658.
[8]
Pandala, S.; Bakshi, V.; Jadi, R.K. Formulation development and in vitro characterization of zolmitriptan controlled release drug delivery systems. INNOSC Theranostics and Pharmacological Sciences, 2019, 2(1), 8-13.
[http://dx.doi.org/10.26689/itps.v2i1.550]
[9]
Damodharan, N. Mathematical modelling of dissolution kinetics in dosage forms. Res. J. Pharm. Technol., 2020, 13(3), 1339-1345.
[http://dx.doi.org/10.5958/0974-360X.2020.00247.4]
[10]
Bao, Q.; Burgess, D.J. Perspectives on physicochemical and in vitro profiling of ophthalmic ointments. Pharm. Res., 2018, 35(12), 234.
[http://dx.doi.org/10.1007/s11095-018-2513-3] [PMID: 30324424]
[11]
Assaf, S.M.; Subhi Khanfar, M.; Bassam Farhan, A.; Said Rashid, I.; Badwan, A.A. Preparation and characterization of co-processed starch/MCC/chitin hydrophilic polymers onto magnesium silicate. Pharm. Dev. Technol., 2019, 24(6), 761-774.
[http://dx.doi.org/10.1080/10837450.2019.1596131] [PMID: 30888873]
[12]
Fartiyal, A.; Arya, R.K.K.; Pal, G.R. Extraction and evaluation of mucilage of persea duthiei as a tablet binder. J. Drug Deliv. Ther., 2019, 9(3-s), 1154-1163.

Rights & Permissions Print Cite
Article Metrics
7
© 2024 Bentham Science Publishers | Privacy Policy