Pharmaceuticals are the chemical molecules which were invented to improve the life of
living things through diagnosing, curing, treating, or preventing diseases. Pharmaceuticals can do
their maximum function or work against disease or prevent from harmful effects of diseases only if
they are free from impurities. The pharmaceutical analysis consists of different essential and important
procedures to ascertain “identity, strength, quality and purity” of drug molecules. There are
three different possibilities to originate impurities, which include (i) at the developmental stages of
pharmaceuticals, (ii) at the time of transportation, and (iii) storage conditions. Therefore, the pharmaceuticals
must be examined at all stages and the impurities should be discovered and quantified.
The pharmaceutical analysis also admits that the analysis of intermediates and raw materials during
the synthesis of drug molecules. Instrumentation is required to perform pharmaceutical analysis
and methods can be developed to certain required levels. This review affords the basic theory of
UV-Visible spectrophotometry and its applications, pharmaceutical method development and validation,
and a list of some reported spectrophotometric methods, which are employed in pharmaceutical
analysis from 2011 to 2020.