During the last decade, the results of large-scale, randomized, clinical trials on newer antidiabetic
agents, glucagon-like peptide-1 (GLP-1) receptor agonists and sodium glucose cotransporter type 2 (SGLT2) inhibitor,
have been published showing promising findings on cardiovascular and renal outcomes. Besides improving
glycemic control, GLP-1 receptor agonists have been shown to modify cardiovascular risk factors,
such as insulin resistance, body weight, blood pressure (BP), and lipid profile. Additionally, SGLT2 inhibitors
except for glycemic control have been shown to induce weight loss and decrease BP. However, there are limited
data regarding their effect on patients without diabetes. Therefore, the aim of the present review is to summarize
the existing literature data regarding the effects of newer antidiabetic therapies on patients without diabetes.