Background: Citrus limon, a Mediterranean-grown citrus species of plants belonging to
the Rutaceae family, occupies a place of an impressive range of food and medicinal uses with considerable
value in the economy of the fruit of the country. Citrus fruits are economically important with
large-scale production of both the fresh fruits and industrially processed products. The extracts and
phytochemicals obtained from all parts of C. limon have shown immense therapeutic potential because
of their anticancer, anti-tumor and anti-inflammatory nature, and also serve as an important
ingredient in the formulation of several ethnic herbal medicines. These properties are mediated by the
presence of different phytochemicals, vitamins and nutrients in the citrus fruits.
Material and Methods: The methods involved in the preparation of the present article included the
collection of information from various scientific databases, indexed periodicals, and search engines
such as Medline Scopus google scholar PubMed, PubMed central web of science, and science direct.
Results: This communication presents an updated account of different pharmacological aspects of C.
limon associated with its anti-oxidative, antiulcer, antihelmintic, insecticidal, anticancer, cytotoxic,
and estrogenic activities. In addition, C. limon extracts possess hepatoprotective, anti-hyperglycemic,
and antimicrobial properties. The present article includes the structure and function of different key
chemical constituents from different parts of C. limon. Also, the possible molecular mechanisms of
actions of bioactive compounds from C. limon are displayed.
Conclusion: The traditional and ethno-medicinal literature revealed that C. limon is very effective in
different pathologies. Most of these compounds possessing antioxidant properties would be implicated
in offering health benefits by acting as potential nutraceuticals to humans with special reference to
disease management of health and disease.