Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity

Author(s): Feng Song*, Yunqiang Bian, Jing Liu, Zhenghua Li, Li Zhao, Junman Fang, Yonghong Lai, Meng Zhou

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 5 , 2021


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Abstract:

Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in natural and synthetic sources since its derivatives possess fascinating structural diversity and various therapeutic properties. Indole alkaloids, synthetic dimers and hybrids could act on diverse targets in cancer cells, and consequently, possess potential antiproliferative effects on various cancers both in vitro and in vivo. Vinblastine, midostaurin, and anlotinib as the representative of indole alkaloids, synthetic dimers and hybrids respectively, have already been clinically applied to treat many types of cancers, demonstrating indole alkaloids, synthetic dimers and hybrids are useful scaffolds for the development of novel anticancer agents. Covering articles published between 2010 and 2020, this review emphasizes the recent development of indole alkaloids, synthetic dimers and hybrids with potential in vivo therapeutic application for cancers.

Keywords: Indole alkaloids, Dimers, Hybrids, In vivo, Cancer, Mechanisms of action.

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Article Details

VOLUME: 21
ISSUE: 5
Year: 2021
Published on: 08 September, 2020
Page: [377 - 403]
Pages: 27
DOI: 10.2174/1568026620666200908162311
Price: $65

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