Background: Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been
linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal anti-inflammatory
drugs (NSAIDs). The search for new anti-ulcer therapeutic agents has been the subject of several studies. Recently, the
gastroprotective effect of Celtis iguanaea has been reported, with linoleic acid (LA) responsible for many of the
therapeutic effects of this medicinal plant.
Aim: This study aims to investigate the gastroprotective activity and the possible mechanisms in which LA may be
involved, through different experimental assays in mice.
Methods: The gastroprotective activity LA was evaluated in the ulcer induced by indomethacin, HCl/EtOH, hypothermicrestraint stress and pyloric ligation. For the gastroprotective mechanisms investigation the quantification of the volume
(mL), pH and total acidity of gastric secretion were considered.
Results: The oral administrations of 25 mg/kg, 50 mg/kg or 100 mg/kg of body weight of LA were capable of protecting
the gastric mucosa against HCl/ethanol (10 mL/kg p.o.), and oral administrations of 50 mg/kg LA showed protection from
ulcers induced by indomethacin, hypothermic-restraint stress and pyloric ligation.
Conclusion: The results of this study show the gastroprotective role of LA in gastric mucosal damage induced by all
assayed distresses. The observed gastroprotection possibly occurs due to the mediated increase of mucosal defensive