Background: RNA splicing, a fundamental step in gene expression, is aimed at intron removal
and ordering of exons to form the protein’s reading frame.
Objective: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities
that lead to tumor progression emerge as targets for therapeutic intervention.
Methods: We discuss the role of aberrant mRNA splicing in carcinogenesis and drug response.
Results and Conclusion: Pharmacological modulation of RNA splicing sets the stage for treatment
approaches in situations where mRNA splicing is a clinically meaningful mechanism of the disease.
Keywords: Cancer, molecular drug targets, RNA splicing, therapy, protein kinase inhibitors.
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