The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of
risk assessment, rapid spreading ability, and propensity to precipitate severe disease in comorbid
conditions. In an attempt to fulfill the demand for prophylactic and treatment measures
to intercept the ongoing outbreak, the drug development process is facing several obstacles
and renaissance in clinical trials, including vaccines, antivirals, immunomodulators,
plasma therapy, and traditional medicines. This review outlines the overview of SARS-CoV-2
infection, significant recent findings, and ongoing clinical trials concerning current and future
therapeutic interventions for the management of advancing pandemic of the century.