Background: Quinoline is considered to be a privileged heterocyclic ring owing to its presence in
diverse scaffolds endowed with promising activity profiles. In particular, quinoline containing compounds have
exhibited substantial antiproliferative effects through the diverse mechanism of actions, which indicates that the
heteroaryl unit is flexible as well as accessible to subtle structural changes that enable its inclusion in chemically
distinct anti-tumor constructs.
Methods: Herein, we describe a medicinal chemistry perspective on quinolines as anticancer agents by digging
into the peer-reviewed literature as well as patents published in the past few years.
Results: This review will serve as a guiding tool for medicinal chemists and chemical biologists to gain insights
about the benefits of quinoline ring installation to tune the chemical architectures for inducing potent anticancer
Conclusion: Quinoline ring containing anticancer agents presents enough optimism and promise in the field of
drug discovery to motivate the researchers towards the continued explorations on such scaffolds. It is highly
likely that adequate efforts in this direction might yield some potential cancer therapeutics in the future.