Title:Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs
VOLUME: 21 ISSUE: 8
Author(s):Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez , Hugo Valdés and David Morales-Morales*
Affiliation:Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de México, C.P. 04510, Facultad de Ciencias Químicas, Universidad Veracruzana, Oriente 6 1009, Col. Rafael Alvarado, C.P. 94340, Orizaba, Veracruz, Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales s/n. CP 83000. Hermosillo, Sonora, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de México, C.P. 04510, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de México, C.P. 04510
Keywords:Cytotoxicity, fluorinated complexes, NHC complexes, cancer, N-heterocyclic carbene (NHC), fluorine, metallodrugs.
Abstract:In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and
medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized
and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives,
including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced
biological properties and turning them into excellent candidates for the development of novel metallodrugs.
Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and
their impact on cancer treatment.
