Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs

Author(s): Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez, Hugo Valdés, David Morales-Morales*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 21 , Issue 8 , 2021


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Abstract:

In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.

Keywords: Cytotoxicity, fluorinated complexes, NHC complexes, cancer, N-heterocyclic Carbene (NHC), fluorine, metallodrugs.

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Article Details

VOLUME: 21
ISSUE: 8
Year: 2021
Published on: 09 April, 2021
Page: [938 - 948]
Pages: 11
DOI: 10.2174/1871520620666200908103452
Price: $65

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