Role of Serum β-HCG Doubling in Diagnosis of Early Pregnancy and its Management Strategy

Author(s): Divya Mirji, Shubha Rao*, Akhila Vasudeva, P.S. Roopa

Journal Name: Current Women`s Health Reviews

Volume 17 , Issue 1 , 2021

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Graphical Abstract:


Background: Pregnancy of unknown location (PUL) is defined as the absence of intrauterine or extrauterine sac and Beta Human Chorionic Gonadotropin levels (β-HCG) above the discriminatory zone of 1500 mIU/ml. It should be noted that PUL is not always an ectopic; however, by measuring the trends of serum β-HCG, we can determine the outcome of a PUL.

Objective: This study aims to identify the various trends of β-HCG levels in early pregnancy and evaluate the role of β-HCG in the management strategy.

Methods: We conducted a prospective observational study of pregnant women suspected of early pregnancy. Cases were classified as having a pregnancy of unknown location (PUL) by transvaginal ultrasound and ß -HCG greater than 1000 mIU/ml. Expectant management was done until there was a definite outcome. All the collected data were analyzed by employing the chi-square test using SPSS version 20.

Results: Among the 1200 women who had early first trimester scans, 70 women who fulfilled our criteria of PUL and ß -HCG > 1000 mIU/ml were recruited in this study. In our study, the mean age of the participants was 30±5.6yrs, and the overall mean serum ß -HCG was 3030±522 mIU/ml. The most common outcome observed was an ectopic pregnancy, 47% in our study. We also found that the rate of failing pregnancy was 27%, and that of intrauterine pregnancy (IUP) was 25%. Overall, in PUL patients diagnosed with ectopic pregnancy, 9% behaved like IUP, and 4% had an atypical trend in their ß -HCG. Those who had an IUP, 11% had a suboptimal increase in ß-HCG.

Conclusion: PUL rate in our unit was 6%. The majority of the outcome of PUL was ectopic in our study. Every case of PUL should be managed based on the initial ß -HCG values, clinical assessments and upon the consent of the patient.

Keywords: Pregnancy of unknown location, ectopic pregnancy, ß-HCG, atypical trends, patient, intrauterine pregnancy (IUP).

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Article Details

Year: 2021
Published on: 22 January, 2021
Page: [86 - 91]
Pages: 6
DOI: 10.2174/1573404816999200905140919
Price: $65

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