Generic placeholder image

Recent Advances in Computer Science and Communications

Editor-in-Chief

ISSN (Print): 2666-2558
ISSN (Online): 2666-2566

General Research Article

Pathological Analysis of Blood Cells Using Deep Learning Techniques

Author(s): Virender Ranga*, Shivam Gupta, Priyansh Agrawal and Jyoti Meena

Volume 15, Issue 3, 2022

Published on: 04 September, 2020

Article ID: e180322185564 Pages: 7

DOI: 10.2174/2666255813999200904113251

Price: $65

Abstract

Introduction: Pathologists are majorly concerned with detecting the diseases and helping the patients in their healthcare and well-being. The present method used by pathologists for this purpose is manually viewing the slides using a microscope and other instruments. However, this method has a number of limitations such as there is no standard way of diagnosis, there are certain chances of human errors and besides, it burdenizes the laboratory personnel to diagnose a large number of slides on a daily basis.

Method: The slide viewing method is widely used and converted into digital form to produce high resolution images. This enables the area of deep learning and machine learning to get an insight into this field of medical sciences. In the present study, a neural based network has been proposed for classification of blood cells images into various categories. When an input image is passed through the proposed architecture and all the hyper parameters and dropout ratio values are applied in accordance with the proposed algorithm, then the model classifies the blood images with an accuracy of 95.24%.

Result: After training the models on 20 epochs. The plots of training accuracy, testing accuracy and corresponding training loss, and testing loss for the proposed model is plotted using matplotlib and trends.

Discussion: The performance of the proposed model is better than the existing standard architectures and other works done by various researchers. Thus, the proposed model enables the development of pathological system which will reduce human errors and daily load on laboratory personnel. . This can also in turn help the pathologists in carrying out their work more efficiently and effectively.

Conclusion: In the present study, a neural based network has been proposed for classification of blood cells images into various categories. These categories have significance in the medical sciences. When input image is passed through the proposed architecture and all the hyper parameters and dropout ratio values are used in accordance with the proposed algorithm, then the model classifies the images with an accuracy of 95.24%. This accuracy is better than the standard architectures. Further, it can be seen that the proposed neural network performs better than the present related works carried out by various researchers.

Keywords: Neural network, Mononuclear, Polynuclear, White blood cell, Classification, Pathology

[1]
J. Puttamadegowda, and S.C. Prasannakumar, "White blood cell segmentation using Fuzzy C means and snake", In: 2016 International Conference on Computation System and Information Technology for Sustainable Solutions (CSITSS), 2016, pp. 47-52.
[http://dx.doi.org/10.1109/CSITSS.2016.7779438]
[2]
Z.K. Alreza, and A. Karimian, "Design a new algorithm to count white blood cells for classification leukemic blood image using machine vision system", In 2016 6th International Conference on Computer and Knowledge Engineering (ICCKE), 2016pp. 251-256
[http://dx.doi.org/10.1109/ICCKE.2016.7802148]
[3]
H. Singh, N. Dhanak, H. Ansari, and K. Kumar, "HDML: Habit detection with machine learning", In: Proceedings of the 7th International Conference on Communication & Computational Technologies (ICCCT), 2017, pp. 29-33.
[4]
K. Kumar, and D.D. Shrimankar, "F-DES: Fast and deep event summarization", IEEE Trans. Multimed., vol. 20, no. 2, pp. 323-334, 2017.
[http://dx.doi.org/10.1109/TMM.2017.2741423]
[5]
S. Sharma, K. Kumar, and N. Singh, "D-FES: Deep facial expression recognition system", Conference on Information and Communication Technology (CICT), 2017pp. 1-6
[6]
K. Kumar, and D.D. Shrimankar, "Deep event learning boost-up approach: Delta", Multimedia Tools Appl., vol. 77, no. 20, pp. 26635-26655, 2018.
[http://dx.doi.org/10.1007/s11042-018-5882-z]
[7]
M.J. Macawile, V.V. Quiñones, A. Ballado, J.D. Cruz, and M.V. Caya, "White blood cell classification and counting using convolutional neural network", In: 3rd International Conference on Control and Robotics Engineering (ICCRE), 2018, pp. 259-263.
[http://dx.doi.org/10.1109/ICCRE.2018.8376476]
[8]
I. Goodfellow, Y. Bengio, and A. Courville, Deep Learning. MIT press, vol. 1, p. 800, 2016.
[9]
Y. LeCun, L. Bottou, and P. Haffner, "Gradient-based learning applied to document recognition", Proc. IEEE, vol. 86, no. 11, pp. 2278-2324, Nov 1998.
[http://dx.doi.org/10.1109/5.726791]
[10]
A. Krizhevsky, I. Sutskever, and G.E. Hinton, "Imagenet classification with deep convolutional neural networks", Adv. Neural Inf. Process. Syst., vol. 25, pp. 1097-1105, Dec 2012.
[11]
K. Simonyan, and A. Zisserman, "Very deep convolutional networks for large-scale image recognition", arXiv, 2014.
[12]
K. He, X. Zhang, S. Ren, and J. Sun, "Deep residual learning for image recognition", In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016pp. 770-778
[13]
C. Szegedy, V. Vanhoucke, S. Ioffe, J. Shlens, and Z. Wojna, "Rethinking the inception architecture for computer vision", In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016pp. 2818-2826
[http://dx.doi.org/10.1109/CVPR.2016.308]
[14]
G. Huang, Z. Liu, L. Van Der Maaten, and K.Q. Weinberger, "Densely connected convolutional networks", In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2017pp. 4700-4708
[15]
A. G. Howard, M. Zhu, B. Chen, D. Kalenichenko, W. Wang, T. Weyand, M. Andreetto, and H. Adam, "Mobilenets: Efficient convolutional neural networks for mobile vision applications", arXiv, 2017.
[16]
M. Sandler, A. Howard, M. Zhu, A. Zhmoginov, and L.C. Chen, "Mobilenetv2: Inverted residuals and linear bottlenecks", In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2018pp. 4510-4520
[17]
B. Zoph, V. Vasudevan, J. Shlens, and Q.V. Le, "Learning transferable architectures for scalable image recognition", In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2018pp. 8697-8710
[http://dx.doi.org/10.1109/CVPR.2018.00907]
[18]
T. Rosyadi, "A. Arifans clustering based on geometry features", In 2016 6th International Annual Engineering Seminar (InAES), 2016pp. 245-249
[http://dx.doi.org/10.1109/INAES.2016.7821942]
[19]
A. Gautam, P. Singh, B. Raman, and H. Bhadauria, “Automatic classification of leukocytes using morphological features and naïve Bayes classifier” In 2016 IEEE Region 10 Conference., TENCON, 2016, pp. 1023-1027.
[http://dx.doi.org/10.1109/TENCON.2016.7848161]
[20]
W. Yu, J. Chang, C. Yang, L. Zhang, H. Shen, Y. Xia, and J. Sha, "Automatic classification of leukocytes using deep neural network", In 2017 IEEE 12th International Conference on ASIC (ASICON), 2017pp. 1041-1044
[http://dx.doi.org/10.1109/ASICON.2017.8252657]
[21]
F. Novoselnik, R. Grbić, I. Galić, and F. Dorić, "Automatic white blood cell detection and identification using convolutional neural network", In 2018 International Conference on Smart Systems and Technologies (SST), 2018pp. 163-167
[http://dx.doi.org/10.1109/SST.2018.8564625]
[22]
R. Ahasan, A.U. Ratul, and A.S. Bakibillah, "White blood cells nucleus segmentation from microscopic images of strained peripheral blood film during leukemia and normal condition", In 2016 5th International Conference on Informatics, Electronics and Vision (ICIEV), 2016pp. 361-366
[http://dx.doi.org/10.1109/ICIEV.2016.7760026]
[23]
S. Laddha, "Analysis of white blood cell segmentation techniques and classification using deep convolutional neural network for leukemia detection", HELIX, vol. 8, pp. 4519-4524, Oct 2018.
[http://dx.doi.org/10.29042/2018-4519-4524]
[24]
P. Mooney, "Blood Cell Images", [Online]. Available at:", https://www.kaggle.com/paultimothymooney/bloodcells#:~: text=Content,Lymphocyte%2C%20Monocyte%2C%20and %20Neutrophil [Accessed on 14-Dec-2021].

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy