Aim: To develop a co-crytsal of Telmisartan for enhancing its solubility in water.
Background: Intermolecular interaction happens in crystal packing; it utilizes and helps to understand
the design of new solid with their respective chemical and physical properties called crystal engineering.
It is a blueprint of molecular solids with specific chemical and physical properties
through an understanding and handling of intermolecular interaction for increasing the solubility,
in case of poor water-soluble drugs.
Objectives: The study was taken under consideration with an aim to generate and synthesize a cocrystal
form of Telmisartan (TEL) with L-lysine to improve its water solubility, dissolution, and micrometric
Methods: Using dry grinding technique, solvent evaporation and cooling crystallization, the results
revealed a generation of co-crystals with enhanced solubility by liquid drop grinding method.
Hence, this process was further explored to investigate various formulations and process parameters
that could significantly affect the crystal solubility, dissolution, and micrometric properties.
Results: The solubility of TEL co-crystals was enhanced by L-lysine. Further, the optimized batch
was subjected to its micrometric evaluation and physiochemical characterization like FT-IR, NMR,
PXRD. The result of the micrometric evaluation showed better results as compared to standards.
The dissolution studies also showed a better dissolution rate for TEL co-crystal tablets than TEL
Conclusion: Co-crystals of TEL with L-lysine showed better solubility and dissolution rate.