Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility

Author(s): Fátima de Lourdes Ochoa-González, Irma E. González-Curiel, Alberto R. Cervantes-Villagrana, Julio C. Fernández-Ruiz, Julio E. Castañeda-Delgado*

Journal Name: Current Molecular Medicine

Volume 21 , Issue 4 , 2021


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Abstract:

Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose and by high concentrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in peripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 - 79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions. We show that in these patients a compromised innate immune response increases susceptibility to infections.

Keywords: Innate response, phagocytosis, Type 2 Diabetes Mellitus, infection, antimicrobial peptide, innate immune cells.

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Article Details

VOLUME: 21
ISSUE: 4
Year: 2021
Published on: 01 June, 2021
Page: [318 - 331]
Pages: 14
DOI: 10.2174/1566524020999200831124534
Price: $65

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