Ionic Liquid Catalyzed Efficient Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles Under Metal and Solvent Free Conditions

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Author(s): Abid H. Banday*, Victor J. Hruby

Journal Name: Current Organocatalysis

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Background: Unprecedented, one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles through azide- aldehyde (3+2) organo-click cycloaddition under metal and solvent-free conditions, is described.

Objective: Solvent and metal free synthesis of biologically and industrially important triazoles.

Methods: Efficient and high yielding synthesis of products avoiding the tedious high solvent workups and chromatographic separations. The synthesis doesn’t involve the routine acetylenes which are very costly but instead cheaper starting materials like aldehydes and organic azides are used.

Results: Green protocol based on the catalysis through Ionic Liquids which simultaneously act as solvents. The products are obtained in good to excellent yields in hassle free synthesis.

Conclusion: Efficient and green synthesis of structurally and biologically important triazoles.

Keywords: Solvent-free reactions, Metal free reactions, Enolizable aldehydes, 1, 2, 3-Triazoles, Regioselective reactions, Non-CuAAC, Ionic Liquids.

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(E-pub Ahead of Print)
DOI: 10.2174/2213337207999200831105105
Price: $95

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