Background: Unprecedented, one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles through azide-
aldehyde (3+2) organo-click cycloaddition under metal and solvent-free conditions, is described.
Objective: Solvent and metal free synthesis of biologically and industrially important triazoles.
Methods: Efficient and high yielding synthesis of products avoiding the tedious high solvent workups and chromatographic
separations. The synthesis doesn’t involve the routine acetylenes which are very costly but instead cheaper starting
materials like aldehydes and organic azides are used.
Results: Green protocol based on the catalysis through Ionic Liquids which simultaneously act as solvents. The products
are obtained in good to excellent yields in hassle free synthesis.
Conclusion: Efficient and green synthesis of structurally and biologically important triazoles.