Elevated Urinary and Blood Vascular Cell Adhesion Molecule-1 as Potential Biomarkers for Active Systemic Lupus Erythematosus: A Meta-analysis

Author(s): Yuan-Rui Xia, Yan-Mei Mao, Jun-Ping Wang, Qing-Ru Li, Yin-Guang Fan, Hai-Feng Pan*, Dong-Qing Ye*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 46 , 2020


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Abstract:

Objective: Due to the inconsistent results of current studies on the association between urinary and blood vascular cell adhesion molecule-1 (VCAM-1) and systemic lupus erythematosus (SLE) disease activity, we conducted this study and analyzed its influencing factors.

Methods: A literature search was conducted in PubMed, EMBASE, Web of Science, and Cochrane Library. Data were extracted from eligible studies to calculate standardized mean differences (SMD) with 95% confidence intervals (CI). Cochrane Q test and I2 statistics were used to examine heterogeneity. The sources of heterogeneity were assessed through sensitivity analysis and subgroup analysis. Publication bias was evaluated by funnel plots and Egger's test.

Results: A total of 15 studies met the inclusion criteria, including 473 active SLE patients and 674 inactive SLE patients. The random effects model was used for data analysis. In both urine and blood samples, VCAM- 1 level in active SLE patients was significantly higher than those in inactive SLE patients (urine: SMD: 0.769; 95% CI: 0.260-1.278; blood: SMD=0.655, 95% CI: 0.084-1.226). No publication bias was found in this study.

Conclusion: Compared with inactive SLE patients, patients with active SLE have higher levels of VCAM-1 in both urine and blood. VCAM-1 may be a potential indicator of SLE disease activity.

Keywords: Systemic lupus erythematosus, vascular cell adhesion molecule-1, disease activity, meta-analysis, urine, blood.

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Article Details

VOLUME: 26
ISSUE: 46
Year: 2020
Published on: 30 December, 2020
Page: [5998 - 6006]
Pages: 9
DOI: 10.2174/1381612826666200826135929
Price: $65

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