Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review

Author(s): Bin Zhang, Ting Zhang, Jianzhou Xu, Jian Lu, Panpan Qiu, Tingting Wang*, Lijian Ding*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 19 , 2020


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Abstract:

Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

Keywords: Sponge-associated fungi, natural products, antimicrobial, antiviral, cytotoxic, lead drugs.

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Article Details

VOLUME: 20
ISSUE: 19
Year: 2020
Published on: 28 December, 2020
Page: [1966 - 2010]
Pages: 45
DOI: 10.2174/1389557520666200826123248
Price: $65

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