Marine sponge-associated fungi are promising sources of structurally interesting and bioactive
secondary metabolites. Great plenty of natural products have been discovered from spongeassociated
fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated
with sponges in 2010-2018. These molecules comprised eight different structural classes, including
alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds
demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review
systematically summarized the structural diversity, biological function, and future potential of
these novel bioactive natural products for drug discovery.