CDI Cross-linked Nanosponges of Citronella Oil for Controlled Mosquito-repellent Activity

Author(s): Pooja Dubey, Pravin Shende*

Journal Name: Current Nanomaterials

Volume 5 , Issue 3 , 2020

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Graphical Abstract:


Background: Citronella oil is considered one of the effective mosquito- repellent oil and in cooperation of oil into nanosponges will help to prevent its evaporation and enhance its effect.

Objective: The objective of the current research was to formulate and characterize CDI cross-linked nanosponges of citronella oil for controlled mosquito-repellent activity.

Methods: β-cyclodextrin-based nanosponges were prepared by polymer condensation method and encapsulated with citronella oil by the sonication method. A topical cream containing citronella oil-based nanosponges was formulated by the phase inversion temperature method. Particle size, zeta potential, encapsulation efficiency, stability, in vitro release, FTIR and DSC studies were used as characterization parameters.

Results: The particle size of citronella oil encapsulated β-cyclodextrin-based nanosponges was 23.05±3.88 nm. The zeta potential of nanosponges was sufficiently high to prevent aggregation. In vitro studies revealed the controlled release of citronella oil from the nanosponges for 24 h. FTIR and DSC confirmed the interaction of the citronella oil with the nanosponges.

Conclusion: Citronella oil encapsulated nanosponges in the topical formulation is an alternative to synthetic marketed creams for controlled mosquito-repellent activity.

Keywords: Nanosponges, citronella oil, β-cyclodextrin, mosquito-repellent activity, cream, FTIR.

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Article Details

Year: 2020
Published on: 21 December, 2020
Page: [214 - 223]
Pages: 10
DOI: 10.2174/2405461505999200826111952
Price: $58

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