CDI Cross-linked Nanosponges of Citronella Oil for Controlled Mosquito-repellent Activity

Author(s): Pooja Dubey, Pravin Shende*

Journal Name: Current Nanomaterials

Volume 5 , Issue 3 , 2020


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Abstract:

Background: Citronella oil is considered one of the effective mosquito- repellent oil and in cooperation of oil into nanosponges will help to prevent its evaporation and enhance its effect.

Objective: The objective of the current research was to formulate and characterize CDI cross-linked nanosponges of citronella oil for controlled mosquito-repellent activity.

Methods: β-cyclodextrin-based nanosponges were prepared by polymer condensation method and encapsulated with citronella oil by the sonication method. A topical cream containing citronella oil-based nanosponges was formulated by the phase inversion temperature method. Particle size, zeta potential, encapsulation efficiency, stability, in vitro release, FTIR and DSC studies were used as characterization parameters.

Results: The particle size of citronella oil encapsulated β-cyclodextrin-based nanosponges was 23.05±3.88 nm. The zeta potential of nanosponges was sufficiently high to prevent aggregation. In vitro studies revealed the controlled release of citronella oil from the nanosponges for 24 h. FTIR and DSC confirmed the interaction of the citronella oil with the nanosponges.

Conclusion: Citronella oil encapsulated nanosponges in the topical formulation is an alternative to synthetic marketed creams for controlled mosquito-repellent activity.

Keywords: Nanosponges, citronella oil, β-cyclodextrin, mosquito-repellent activity, cream, FTIR.

[1]
Patel EK, Gupta A, Oswal RJ. A review on: mosquito-repellent methods. Int J Pharm Chem Biol Sci 2012; 2: 310-7.
[2]
Leung AY. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. In: New York, NY: J Wiley Sons. New York, NY: J Wiley Sons 1980.
[3]
Shende P, Chaphalkar R, Deshmukh K, Gaud RS. Physicochemical investigation of engineered nanosuspensions containing model drug, lansoprazole. J Dis Sci Tech 2016 2;37; (4): 504-11.
[4]
Mandal S. Repellent activity of Eucalyptus and Azadirachta indica seed oil against the filarial mosquito Culex quinquefasciatus Say (Diptera: Culicidae) in India. Asian Pac J Trop Biomed 2011; 1(1): S109-12.
[http://dx.doi.org/10.1016/S2221-1691(11)60135-4]
[5]
Hazarika H, Tyagi V, Krishnatreyya H, et al. Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes. Acta Trop 2020; 210105573
[http://dx.doi.org/10.1016/j.actatropica.2020.105573] [PMID: 32505595]
[6]
Bezerra FM, Carmona ÓG, Carmona CG, Plath AM, Lis M. Biofunctional wool using β-cyclodextrins as vehiculizer of citronella oil. Proc biochem, 2019; 77: 151-158.
[7]
Temple WA, Smith NA, Beasley M. Management of oil of citronella poisoning. J Toxicol Clin Toxicol 1991; 29(2): 257-62.
[http://dx.doi.org/10.3109/15563659109038618] [PMID: 1675696]
[8]
Crini G, Fourmentin S, Fenyvesi É, Torri G, Fourmentin M, Morin-Crini N. Fundamentals and applications of cyclodextrins. Cyclodextrin fundamentals, reactivity and analysis. In: Cyclodextrin Fundamentals, Reactivity and Analysis 2018; pp. 1-55.
[9]
Lee MY. Essential Oils as Repellents against Arthropods. BioMed Res Int 2018; 20186860271
[http://dx.doi.org/10.1155/2018/6860271] [PMID: 30386794]
[10]
Coviello V, Sartini S, Quattrini L, Baraldi C, Gamberini MC, La Motta C. Cyclodextrin-based nanosponges for the targeted delivery of the anti-restenotic agent DB103: A novel opportunity for the local therapy of vessels wall subjected to percutaneous intervention. Eur J Pharm Biopharm 2017; 117: 276-85.
[http://dx.doi.org/10.1016/j.ejpb.2017.04.028] [PMID: 28456606]
[11]
Caldera F, Argenziano M, Trotta F, et al. Cyclic nigerosyl-1,6-nigerose-based nanosponges: An innovative pH and time-controlled nanocarrier for improving cancer treatment. Carbohydr Polym 2018; 194: 111-21.
[http://dx.doi.org/10.1016/j.carbpol.2018.04.027] [PMID: 29801818]
[12]
Swaminathan S, Pastero L, Serpe L, et al. Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm 2010; 74(2): 193-201.
[http://dx.doi.org/10.1016/j.ejpb.2009.11.003] [PMID: 19900544]
[13]
Momin MM, Zaheer Z, Zainuddin R, Sangshetti JN. Extended release delivery of erlotinib glutathione nanosponge for targeting lung cancer. Artif Cells Nanomed Biotechnol 2018; 46(5): 1064-75.
[http://dx.doi.org/10.1080/21691401.2017.1360324] [PMID: 28758795]
[14]
Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R. The application of nanosponges to cancer drug delivery. Expert Opin Drug Deliv 2014; 11(6): 931-41.
[http://dx.doi.org/10.1517/17425247.2014.911729] [PMID: 24811423]
[15]
Minelli R, Cavalli R, Ellis L, et al. Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells. Eur J Pharm Sci 2012; 47(4): 686-94.
[http://dx.doi.org/10.1016/j.ejps.2012.08.003] [PMID: 22917641]
[16]
Sherje AP, Dravyakar BR, Kadam D, Jadhav M. Cyclodextrin-based nanosponges: a critical review. Carbohydr Polym 2017; 173: 37-49.
[http://dx.doi.org/10.1016/j.carbpol.2017.05.086] [PMID: 28732878]
[17]
Pushpalatha R, Selvamuthukumar S, Kilimozhi D. Cyclodextrin nanosponge based hydrogel for the transdermal co-delivery of curcumin and resveratrol: Development, optimization, in vitro and ex vivo evaluation. J Drug Deliv Sci Technol 2019; 52: 55-64.
[http://dx.doi.org/10.1016/j.jddst.2019.04.025]
[18]
Muthuchamy N, Atchudan R, Edison TN, Perumal S, Lee YR. High-performance glucose biosensor based on green synthesized zinc oxide nanoparticle embedded nitrogen-doped carbon sheet. J Electroanal Chem (Lausanne Switz) 2018; 816: 195-204.
[http://dx.doi.org/10.1016/j.jelechem.2018.03.059]
[19]
Caldera F, Tannous M, Cavalli R, Zanetti M, Trotta F. Evolution of Cyclodextrin Nanosponges. Int J Pharm 2017; 531(2): 470-9.
[http://dx.doi.org/10.1016/j.ijpharm.2017.06.072] [PMID: 28645630]
[20]
Brewster M, Estes K, Bodor N. An intravenous toxicity study of 2-hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and monkeys. Int J Pharm 1990; 59(3): 231-43.
[http://dx.doi.org/10.1016/0378-5173(90)90114-J]
[21]
Cavalli R, Trotta F, Tumiatti W. Cyclodextrin-based nanosponges for drug delivery. J Incl Phenom Macro 2006; 56(1-2): 209-13.
[http://dx.doi.org/10.1007/s10847-006-9085-2]
[22]
Shende P, Kulkarni YA, Gaud RS, et al. Acute and repeated dose toxicity studies of different β-cyclodextrin-based nanosponge formulations. J Pharm Sci 2015; 104(5): 1856-63.
[http://dx.doi.org/10.1002/jps.24416] [PMID: 25754724]
[23]
Trotta F, Zanetti M, Cavalli R. Cyclodextrin-based nanosponges as drug carriers. Beilstein J Org Chem 2012; 8: 2091-9.
[http://dx.doi.org/10.3762/bjoc.8.235] [PMID: 23243470]
[24]
Reegan AD, Kannan RV, Paulraj MG, Ignacimuthu S. Synergistic effects of essential oil-based cream formulations against Culex quinquefasciatus Say and Aedes aegypti L.(Diptera: Culicidae). J Asia-Pac Entanol 2014; 17(3): 27-331.
[http://dx.doi.org/10.1016/j.aspen.2014.02.008]
[25]
Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study. AAPS PharmSciTech 2011; 12(1): 279-86.
[http://dx.doi.org/10.1208/s12249-011-9584-3] [PMID: 21240574]
[26]
Chamorro ER, Zambon SN, Morales WG, Swqueira AF, Velasco GA. Study of the chemical composition of essential oils by gas chromatography. Gas Chromatography in Plant Science, wine technology, toxicology and some specific applications In: Salih B, Çelikbıçak O, eds Gas Chromatography in Plant Science, wine technology, toxicology and some specific applications London: IntechOpen 2012; 307-324.
[27]
Shende PK, Trotta F, Gaud RS, Deshmukh K, Cavalli R, Biasizzo M. Influence of different techniques on formulation and comparative characterization of inclusion complexes of ASA with β-cyclodextrin and inclusion complexes of ASA with PMDA cross-linked β-cyclodextrin nanosponges. J Incl Phenom Macrocycl Chem 2012; 74(1-4): 447-54.
[http://dx.doi.org/10.1007/s10847-012-0140-x]
[28]
Moore SJ, Lenglet A, Hill N. Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. J Am Mosq Control Assoc 2002; 18(2): 107-10.
[PMID: 12083351]
[29]
Pålsson K, Jaenson TG. Plant products used as mosquito repellents in Guinea Bissau, West Africa. Acta Trop 1999; 72(1): 39-52.
[http://dx.doi.org/10.1016/S0001-706X(98)00083-7] [PMID: 9924960]
[30]
Govere J, Durrheim DN, Toit ND, Hunt RN, Coetzee M. Local plants as repellents against Anopheles arabiensis, in Mpumalanga Province, South Africa Cent Afr J Med 2000; 46(8): 213-6.


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Article Details

VOLUME: 5
ISSUE: 3
Year: 2020
Page: [214 - 223]
Pages: 10
DOI: 10.2174/2405461505999200826111952
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