Title:CDI Cross-linked Nanosponges of Citronella Oil for Controlled Mosquito-repellent Activity
VOLUME: 5 ISSUE: 3
Author(s):Pooja Dubey and Pravin Shende*
Affiliation:Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai
Keywords:Nanosponges, citronella oil, β-cyclodextrin, mosquito-repellent activity, cream, FTIR.
Abstract:
Background: Citronella oil is considered one of the effective mosquito-
repellent oil and in cooperation of oil into nanosponges will help to prevent its
evaporation and enhance its effect.
Objective: The objective of the current research was to formulate and characterize
CDI cross-linked nanosponges of citronella oil for controlled mosquito-repellent
activity.
Methods: β-cyclodextrin-based nanosponges were prepared by polymer condensation
method and encapsulated with citronella oil by the sonication method. A
topical cream containing citronella oil-based nanosponges was formulated by the
phase inversion temperature method. Particle size, zeta potential, encapsulation
efficiency, stability, in vitro release, FTIR and DSC studies were used as characterization
parameters.
Results: The particle size of citronella oil encapsulated β-cyclodextrin-based
nanosponges was 23.05±3.88 nm. The zeta potential of nanosponges was sufficiently
high to prevent aggregation. In vitro studies revealed the controlled release
of citronella oil from the nanosponges for 24 h. FTIR and DSC confirmed
the interaction of the citronella oil with the nanosponges.
Conclusion: Citronella oil encapsulated nanosponges in the topical formulation
is an alternative to synthetic marketed creams for controlled mosquito-repellent
activity.
