Title:Identification of Drug Candidates for Breast Cancer Therapy Through Scaffold Repurposing: A Brief Review
VOLUME: 13 ISSUE: 1
Author(s):Jubie Selvaraj*, Thangavelu Prabha and Neetu Yadav
Affiliation:Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandam Palayam Post, Erode-638052, Tamilnadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu
Keywords:Drug repurposing, scaffold, breast cancer, coumarins, statins, NSAIDs, benzimidazole, long-chain fatty acids,
niclosamide, biphosphaonates.
Abstract:Conventional drug discovery is a time consuming and expensive expedition with less
clinical preference achievement proportion intended for breast cancer therapy. Even if numerous
novel approaches to the conformation of drugs have been introduced for breast cancer therapy,
they are yet to be implemented in clinical practice. This tempting strategy facilitates a remarkable
chance to take the entire benefit of existing drugs. Despite drug repurposing significantly decrease
the investigational period and cost, it has got many objections and issues. Scaffold repurposing is
an approach that procures a novel significance on the decrepit motto of “to commencement with a
pristine drug” . Hence, we move into a probable and nearer approach, the exploitation of scaffolds,
which was originally developed for other purposes, including anti-tumor activity. In this review,
we summarize different drugs and scaffolds used in breast cancer therapy.
