Natural Products, the New Intervention Regime of Metabolic Disorders
Pp. 32-122 (91)
Mohamed A. Salem, Dalia I. Hamdan, Islam Mostafa, Rasha Adel, Ahmed Elissawy and Assem M. El-Shazly
Nature is considered an indispensable source of natural products and natural
products-derived drug leads. Over the last decade, the use of natural products-based
medicine (herbal medicine or phytomedicine) has increased tremendously worldwide
especially with the exceeding prevalence of metabolic disorders. Metabolic disorders
are the major worldwide epidemic associated with obesity, diabetes mellitus,
cardiovascular diseases associated with hyperlipidemia, and many other endocrine and
nutrition-related issues. Since metabolic disorders are multi-factorial in their
pathophysiology, they can be targeted by natural products that have synergy between
diverse metabolites. Therefore, it is important to find the proper formulas not only for
the treatment but also for reduction of associated risks and for prophylaxis and
prevention of long-term complications. At the present work, a brief outline of the
pathophysiology of metabolic disorders is provided. Additionally, natural productbased
drug therapies that are currently applied in clinical trials attributed to metabolicrelated
diseases are critically discussed.
Cardiovascular diseases, Clinical trials, Diabetes, Dyslipidemia,
Metabolic disorders, Natural products, Obesity, Osteoporosis, Pathophysiology.
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.