Background: Obesity has been a serious health issue over the last decades, both in the
affluent western world and developing countries. Obesity is linked to major health complications,
such as diabetes, cardiac disorder, cancer, hypertension, sleep apnoea, etc. Available treatments,
such as bariatric surgery and pharmacotherapy are often accompanied by adverse side effects and
poor patient compliance. Nanotechnology is a discipline that is concerned with material characteristics
at the nanoscale, and offers novel techniques for disease detection, management, and prevention.
Objectives: Recent progress in the field of obesity research at its interface with nanotechnology is
the main focus of this study. Nanomedicine has greatly enhanced the health status of the people
suffering from obesity as it provides non-obtrusive techniques for the management and treatment
Methods: Literature survey was performed using PubMed, Science Direct, and Web of Science
search engines with- terms nanotechnology, nanomedicine and obesity. The research focused primarily
on articles published between the years 2000 and 2019.
Results: Original and innovative approaches in the developments of nano-technology based drug
delivery strategies have been described. Nanotechnology has been widely proposed to combine
herbal medicine for the treatment of obesity, because nano-structured systems might be able to potentiate
the action of plant extracts, reducing the required dose and side effects, and improving activity.
This will offer a wide era of treatment options, which will directly improve the patient’s
Conclusion: This review surveys recent developments of nanotechnology-‐based drug delivery
strategies, which are highlighted and discussed for obesity treatment with an emphasis on the enhanced
therapeutic efficiency and minimized side effects. The insights for future development related
to the management of obesity have also been discussed.