Background: Previously human society has faced various unprecedented pandemics in the history and
viruses have majorly held the responsibilities of those outbreaks. Furthermore, due to amplified global connection
and speedy modernization, epidemic outbreaks caused by novel and re-emerging viruses signify potential risk to
community health. Despite great advancements in immunization and drug discovery processes, various viruses
still lack prophylactic vaccines and efficient antiviral therapies. Although, vaccine is a prophylaxes option, but it
cannot be applied to infected patients, hence therapeutic interventions are urgently needed to control the ongoing
global SARS- CoV-2 pandemic condition. To spot the novel antiviral therapy is of decisive importance and
Mother Nature is an excellent source for such discoveries.
Methodology: In this article, prompt high through-put virtual screening for vetting the best possible drug candidates
from natural compounds’ databases has been implemented. Herein, time tested rigorous multi-layered drug
screening process to narrow down 66,969 natural compounds for the identification of potential lead(s) is implemented.
Druggability parameters, different docking approaches and neutralization tendency of the natural products
were employed in this study to screen the best possible natural compounds from the digital libraries.
Conclusion: The results of this study conclude that compounds PALA and HMCA are potential inhibitors of
SARS-CoV-2 spike protein and can be further explored for experimental validation. Overall, the methodological
approach reported in this article can be suitably used to find the potential drug candidates against SARS-CoV2 in
the burning situation of COVID-19 with less expenditure and a concise span of time.