Aim: To design controlled release topical delivery of mupirocin for the treatment
of skin infection.
Background: Mupirocin is an antibacterial drug. Mupirocin works to kill the bacteria,
which include strains of Staphylococcus aureus and Streptococcus pyogenes. It is also used
for the treatment of inflammation of a hair follicle. The half-life of mupirocin is only 20-40
min. It has very slight solubility in water. Patent literature had shown work on ointment, antibiotic
composition, nasal and topical composition. Emulgel is a duel control release system
for the topical delivery of hydrophobic drugs.
Objective: The objective was to formulate emulgel with controlled delivery of mupirocin
using Sepineo P 600.
Methods: Soya oil, tween 80 and polyethylene glycol 400 (Oil:Surfactant:Cosurfactant)
were used for emulsion formulation. Emulgel was optimized by 32 factorial design. Sepineo
P 600 and hydroxy propyl methyl cellulose K4M were used as independent variables. Drug
excipient compatibility analysis was carried out by FTIR, UV and DSC spectra. Emulgel
was evaluated for its physical characterization, in vitro release, ex vivo release, antimicrobial
and anti-inflammatory study.
Results: DSC, UV and FTIR analysis confirmed drug excipient compatibility. FE SEM
showed a size range between 228-255 nm. Zeta potential was found to be -25.1 mV, which
showed good stability of the emulsion. Design expert software showed F2 as an optimized
batch. Release studies indicated that the controlled release of drugs forms Sepineo P 600 gel
due to its higher gelling capacity. Batch F2 showed comparable results with marketed formulation
against Staphylococcus aureus. For batch F2, 40 μg/ml was the minimal inhibitory
Conclusion: Antimicrobial and anti-inflammatory study proved successful development of
stably controlled release mupirocin emulgel.