Title:Recent Approaches on Novel Topical Delivery Systems for Atopic Dermatitis Treatment
VOLUME: 14 ISSUE: 3
Author(s):Emine Kahraman, Neriman Aydilek and Sevgi Güngör*
Affiliation:Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116, Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116, Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116, Istanbul
Keywords:Atopic dermatitis, calcineurin inhibitors, corticosteroids, skin permeation, tacrolimus, nanocarriers.
Abstract:Atopic dermatitis is a chronic inflammatory disease of the skin, which is characterized by
itching, erythema, and eczematous lacerations. It affects about 10 % of adults and approximately 15-20
% of children worldwide. As a result of genetic, immunologic, and environmental factors, the disease
manifests itself with the impaired stratum corneum barrier and then immunological responses. Topical
administration of corticosteroids and calcineurin inhibitors are currently used as the first strategy in the
management of the disease. However, they have low skin bioavailability and some side effects. The
nanocarriers as novel drug delivery systems could overcome limitations of conventional dosage forms,
owing to increment of poorly soluble drug' solubility, then its thermodynamic activity and, consequently,
its skin permeation. Also, side effects of the drug substances on the skin could be reduced by
the nano-sized drug delivery systems due to encapsulation of the drug in the nanocarriers and targeted
drug delivery of drug substances to the inflammated skin areas. Thereby, there have been available
numerous research studies and patents regarding the use of nanocarriers in the management of atopic
dermatitis. This review focuses on the mechanism of disease and development of nanocarrier based on
novel drug release systems in the management of atopic dermatitis.
