Pathway of Inflammation due to Asbestiform Fiber “Fluoro-edenite” Exposure: An Update

Author(s): Caterina Ledda*, Claudia Lombardo, Elisabetta A. Tendi, Maria Hagnas, Gianluca Paravizzini, Vera Filetti, Venerando Rapisarda

Journal Name: Current Respiratory Medicine Reviews

Volume 16 , Issue 2 , 2020


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Abstract:

Fluoro-edenite (FE) is an asbestos-like amphibole present in the bentonitic lavas extracted from a stone quarry in Biancavilla, a village sited in the Etnean Volcanic Area (Italy).

Thoracic pathologies are the results of excessive inflammatory processes that are the early response of the immune system to inhaled fibers. As demonstrated for asbestos, fibers may trigger immune system cells in an acute and/or chronic manner. This review aims to clarify the pathways of inflammation in workers exposed to FE fibers.

Based on the articles reviewed, it seems that a permanent stimulus created by repeatedly inhaling the FE fibers and their persistence in the body can act as a trigger both in promoting inflammatory processes and in the immunological induction of autoimmune disease.

Keywords: Fluoro-edenite, biancavilla, mesothelioma, carcinogenesis, inflammation, cancer, cytokine.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2020
Published on: 18 January, 2021
Page: [73 - 75]
Pages: 3
DOI: 10.2174/1573398X16999200819151645
Price: $65

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