Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy

Author(s): Mengying Xie, Lei Tao, Ziqi Zhang, Wei Wang*

Journal Name: Current Drug Delivery

Volume 18 , Issue 7 , 2021


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Abstract:

Mesenchymal Stem Cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively perform homing to inflammation and tumor sites. This review aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy.

Keywords: Mesenchymal stem cells, tumor-targeted therapy, cell-mediated drug delivery, exosomes, nanoparticles, gene therapy.

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Article Details

VOLUME: 18
ISSUE: 7
Year: 2021
Published on: 19 August, 2020
Page: [864 - 879]
Pages: 16
DOI: 10.2174/1567201817999200819140912
Price: $95

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