Background: Multiple sclerosis (MS) is a chronic disease that affects the central nervous
system. Depression, anxiety and stress are the most common psychiatric comorbidities in MS,
which can have adverse consequences. The aim of this study was to determine the effect of relaxation
(Jacobson and Benson) technique on depression, anxiety and stress in MS patients.
Methods: This clinical trial was conducted since December 2016 to March 2017 in the Multiple
Sclerosis Association and the Neurology Clinic of Farshchian Hospital (Sina) in Hamadan. Sixty
patients with multiple sclerosis were randomly assigned to two experimental (n=30) and control
(n=30) groups. The control group received routine care and experimental group received the relaxation
technique (Jacobson and Benson) in 8 sessions of 60-minute twice a week for 4 weeks in addition
to receiving routine care. The DASS-21 scale was completed by samples before and after the
Results: Results of the study showed that in the intervention group, the scores of depression, anxiety
and stress after using relaxation (Jacobson and Benson) was decreased significantly (P<0.05), while
in the control group no significant decrease was observed (P<0.05).
Conclusion: The results of this study showed that relaxation (Jacobson and Benson) is effective in
reducing depression, anxiety and stress in patients with multiple sclerosis. Therefore, in addition
to prescribing medication, it is suggested that complementary therapies be performed for these