The challenges of viral infection have increased in recent decades due to the emergence of
resistance, cross-resistance and drying up of antiviral drug discovery. Many neglected tropical viruses
including the chikungunya virus, dengue virus & Japanese encephalitis virus have gradually become
global pathogens. This has further increased the burden of viral infection which necessitates the continuous
development of antiviral therapy. The antiviral chemistry began with the development of thiosemicarbazide
derived thiosemicarbazones as antiviral. Although very few thiosemicarbazides have
progressed into clinical application, it still inspires antiviral development. During last 3 decades (1990-
2020), several efforts have been made to develop suitable antiviral by using thiosemicarbazide scaffold.
Its hybridization with other pharmacophores has been used as a strategy to enhance safety and efficacy.
Cyclization and substitution of thiosemicarbazides have also been used to develop potent antiviral.
With the ability to form coordinate bonds, thiosemicarbazides have been used either as metal
complex or chelator against viruses. This work is an attempt to systematically review the research on
the use of thiosemicarbazides as an antiviral scaffold. It also reviews the structure-activity relationship
and translational suitability of thiosemicarbazide derived compounds.
Keywords: Thiosemicarbazide, thiosemicarbazone, virus, antiviral, chikungunya virus, SAR, viral infection.
Rights & PermissionsPrintExport