Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

Author(s): Esmaeil Sheikh Ahmadi, Amir Tajbakhsh, Milad Iranshahy, Javad Asili, Nadine Kretschmer, Abolfazl Shakeri*, Amirhossein Sahebkar

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 19 , 2020


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Abstract:

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

Keywords: Naphthoquinone, cytotoxic, antibacterial, clinical trial, cancer, biological activity.

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Article Details

VOLUME: 20
ISSUE: 19
Year: 2020
Published on: 28 December, 2020
Page: [2019 - 2035]
Pages: 17
DOI: 10.2174/1389557520666200818212020
Price: $65

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