A selected set of new N1-(indan-5-yl)amidrazones 4a-p, encompassing piperazines or
related amines, has been prepared via interaction of the hydrazonoyl chloride 3 (derived from
5-aminoindane) with the appropriate sec-cyclic amine in the presence of triethylamine. Their suggested
structures are supported by IR, 1H NMR, 13C NMR, high-resolution MS (ESI) spectral data, and further
confirmed by single-crystal X-ray crystallography for 4k. These novel compounds were screened for
their antitumor activity against breast cancer cells (MCF7 and T47D); amongst all of them, only compound
4o, incorporating N-(pyrimidin-2-yl)piperazine, was fairly active with IC50 values of 69 μM and
61 μM, respectively.