Background and Aims: To study the prevalence of deranged metabolic parameters in patients
Methods: This was a prospective, cross-sectional observational study conducted at a tertiary level
rheumatology center in Nepal. Patients over 18 years and diagnosed as gout using the ACR/EULAR
2015 classification criteria were included in the study. Known cases of chronic kidney disease,
liver disease and heart diseases were excluded. Baseline demographic data along with records
of weight, waist circumference, lipid profile, glucose profile, blood pressure measurement, serum
uric acid level and inflammatory markers were taken. Diagnosis of metabolic syndrome (MS) was
made according to the National Cholesterol Education Program criteria. Approval was obtained
from the ethical review board of the National Center for Rheumatic Diseases.
Results: A total of 523 patients with gout were enrolled in the study, out of which 97.0% were
male. The mean age at diagnosis was 49.1±12.8 years. Most of the patients were overweight with a
mean BMI of 27.0±3.6 kg/m2. About 8.1% had preexisting diabetes mellitus, 24.6% had hypertension,
5.1% had hypothyroidism and 45.1% had dyslipidemia. Patients fulfilling 2 out of 5 criteria
of MS were 60.6% whereas 30.6% fulfilled 3 out of 5 criteria.
Conclusion: Gout was commonly observed in middle-aged men. The prevalence of metabolic syndrome
and its components was high in patients with gout. Management of gout should also include
screening and management of the metabolic syndrome.