Background: Wound healing is a complex process necessary for repairing damaged
tissues and preventing infection. Selenium nanoparticles (Se NPs) were known due to
their antioxidant and antimicrobial effects, also niacin has angiogenesis and antioxidant effects
that are important in wound healing.
Objective: The present study was conducted to investigate the effect of Se NPs and niacin in
reducing and accelerating the wound healing time in mice.
Methods: A simple wet chemical method has been modified to synthesize Se NPs in order to
investigate their effect and niacin on reducing the wound healing in 80 adult female albino
mice (250 mm2 full thickness open excision wound) that were divided into eight groups (10
mice/each). After 30-days, the mice were sacrificed, blood and tissue samples were taken for
Results: The results showed that the percentage of wound area had been significantly reduced
in Se NPs and niacin treated groups compared to the positive control. The level of
Vascular Endothelial cell Growth Factor and Collagenase I in Se NPs and niacin groups significantly
exceed those of other groups while Nitric Oxide (NO) was significantly decreased
in treated groups. Liver and kidney functions showed the lower toxicity effect of Se NPs and
niacin. Skin tissue showed the wound healing effect of Se NPs and niacin by regenerating
skin layer compared to the positive group.
Discussion: The high antioxidant property and low hemolysis activity of Se NPs and niacin
proved the biocompatible nature of Se NPs and niacin. A possible mechanism depending on
the obtained results has been proposed.
Conclusion: Se NPs and niacin play an important role in accelerating and reducing the time
of wound healing while they were antagonistic to each other.