Musculoskeletal tumors of the hand are a rare entity and are divided into skeletal and
soft tissue tumors. Either category comprises benign and malignant or even intermediate tumors.
Basic radiology allows an optimal resolution of bone and related soft tissue areas, ultrasound and
more sophisticated radiologic tools such as scintigraphy, CT and MRI allow a more accurate evaluation
of tumor extent. Enchondroma is the most common benign tumor affecting bone, whereas
chondrosarcoma is the most commonly represented malignant neoplasm localized to hand bones.
In the soft tissues, ganglions are the most common benign tumors and epithelioid sarcoma is the
most frequently represented malignant tumor targeting hand soft tissues. The knowledge regarding
diagnostic and therapeutic management of these tumors is often deriving from small case series, retrospective
studies or even case reports. Evidences from prospective studies or controlled trials are
limited and for this lack of clear and supported evidences, data from the medical literature on the
topic are controversial, in terms of demographics, clinical presentation, diagnosis, prognosis and
therapy. The correct recognition of the specific subtype and extension of the tumor through first
line and second line radiology is essential for the surgeon, in order to effectively direct the therapeutic