Frontiers in Enzyme Inhibition

Frontiers in Enzyme Inhibition

Enzyme Inhibition - Environmental and Biomedical Applications

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for ...
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Enzyme Inhibition Applications in Treatment of Neurological Disorders

Pp. 263-287 (25)

D. Lokapriya and P.K. Praveen Kumar

Abstract

Enzyme inhibitors are widely prescribed drugs for many diseases including neurological disorders and today most of the drugs are enzyme inhibitors and are in the clinical/pre-clinical phase of the drug discovery. For many of the neurological disorders, especially neurodegenerative disorders, only symptomatic therapy is available rather than the therapy based on an understanding of the mechanism of these diseases. In this case, enzyme inhibitors become the solution as they inhibit the action of enzymes whose abnormal activity may be one of the causes of the disease. They also halt the progression of the disease and alleviate the symptoms. This chapter focuses on some of the enzyme inhibitors that have been prescribed as drugs for neurological disorders, their mechanism of action and discuss some inhibitors that are still in their research level of development.

Keywords:

Drug discovery, Enzyme Inhibitors, Neurological disorders, Symptomatic therapy.

Affiliation:

Department of Biotechnology, Sri Venkateswara College of Engineering (Autonomous), Sriperumbudur Tk, 602117, Tamilnadu, India