Background: To date, no study has been performed on the relationship between depression
and perimenopausal symptoms using the Path model in Iran.
Objective: This study aims to assess the relationship between depression and menopause symptoms
using the PATH model.
Methods: A cross-sectional study was conducted for 4 months, in 2019, and 332 menopausal
women were enrolled in 14 public health centers. Data collection instruments included questionnaires
of demographic characteristics, anxiety instrument, Menopause Rating Scale, and the Beck
Depression short Inventory (BDI-S). The hypothesized mediators were assessed using Structural
Equation Modeling (SEM). The model included depression symptoms (dependent variable), anxiety
(mediators), number of alive children (moderator), and menopausal symptoms (independent variable).
Analyses were conducted by SPSS 16 and AMOS 20.
Results: There was a significant positive correlation between menopause symptoms with total anxiety
(Rs=0.52), state anxiety (Rs=0.47), trait anxiety (Rs=0.46), and depression (Rs=0.54). Depression
had a significant positive correlation with total anxiety (Rs=0.64), trait anxiety (Rs=0.58), and state
anxiety (Rs=0.59). Also, the total mediating effect of total anxiety and depression and the total
moderating effect of the number of alive children were significant on menopause symptoms.
Conclusion: According to the results of the present study, there is an association between depression
and menopausal symptoms. Therefore, health providers should pay more attention to the psychological
health of women during the perimenopausal period. The predictor factors should be considered
in both intervention and clinical assessment of menopause women.