Green separation science involves extraction, pre-concentration and chromatographic
analysis aiming at minimizing environmental impact by reducing energy and reagent usage and reducing
or eliminating waste generation. However, the enrichment of trace analytes and/or the analysis
of complex matrices most frequently require several steps before analysis, such as extraction,
pre-concentration, clean up and preparative chromatography. Thus, alternative and greener separation
techniques and solvents are replacing classical methods to diminish the carbon footprint and increase
sustainability. Moreover, many innovations are also emerging to curtail the environmental
impact of samples analysis; such as micro or nano analytical platforms, sensor-based systems and
direct injection to high-resolution mass spectrometry. The current review provides an updated account
of the green and sustainable separation science techniques. The current innovations on greener
separations and their application in different fields of study are discussed.
Keywords: Sustainable chemistry, green separation science, alternative sample preparation, micro-analytical techniques, multidimensional
chromatography, green chromatography.
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