Title:Solid Lipid Particle-loaded <I>Ocimum Gratissimum</I> Seed Films and Polymeric Films for Controlled Drug Delivery
VOLUME: 10 ISSUE: 4
Author(s):Hang D. Mai, Phuong H.L. Tran and Thao T.D. Tran*
Affiliation:Former student at International University, Ho Chi Minh City, School of Medicine, Deakin University, Geelong, Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City
Keywords:Solid lipid particles, controlled release, sodium fusidate, Ocimum gratissimum seed, polymeric film, drug delivery.
Abstract:
Aims: The purpose of this study was to investigate and compare the formation of polymeric
and Ocimum gratissimum seed films containing solid lipid particles for controlled drug release.
Methods: The hot homogeneous method was selected to form solid lipid particles containing sodium
fusidate to load the drug into the film. The in vitro drug release and drug permeability of the films were
tested with dialysis tubes and the Franz diffusion cell method, respectively. The mucoadhesive time
and swelling and erosion rates were also studied.
Results: The solid lipid particles showed the ability to form Ocimum gratissimum seed and polymeric
films for use in drug delivery. Although the polymeric matrix yielded excellent swelling and erosion
rates, leading to a faster drug release rate and drug permeation than that of the Ocimum gratissimum
seed film, the mucoadhesive time of the polymer film was worse than that of the seed film.
Conclusion: Therefore, the characteristics of the individual systems may be further studied in a combined
system to take full advantage of both in the desired film.
