Background: Chronic stress elevates the cortisol beyond normal levels, which affects
cognition including learning & memory. This injurious effect is primarily mediated via over excitation
of metabotropic glucocorticoid receptors (mGR).
Methods: The present study was aimed to appraise the neuroprotective effects of naturally occurring
molecule β-1,3-glucan by interfering with stress-cortisol-mGR axis. Our data of virtual
screening (in silico) exhibited the promising interactions of β-glucan with the mGR. Therefore, the
study was extended to evaluate its efficacy (2.5, 5 and 10 mg/kg/ i.p) in an animal model of chronic
unpredictable mild stress (CUMS, 28 days) induced memory impairment.
Results: Results of the current study revealed the β-glucan provided dose dependent protection
against deleterious effects of stress on learning and memory associated parameters observed in
Morris water maze (MWM) task. At higher tested doses, it has also significantly antagonized the
stress induced weight loss and corticosterone elevation.