Title:Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence
VOLUME: 21 ISSUE: 5
Author(s):Mohammad H. Pourhanifeh, Reza Mottaghi, Zahra S. Razavi, Alimohammad Shafiee, Sarah Hajighadimi and Hamed Mirzaei*
Affiliation:Halal Research Center of IRI, FDA, Tehran, Department of Oral and Maxillofacial Surgery, Kashan University of Medical Sciences, Kashan, School of Medicine, Kashan University of Medical Sciences, Kashan, Division of General Internal Medicine, Toronto General Hospital, Toronto, ON, Division of General Internal Medicine, Toronto General Hospital, Toronto, ON, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan
Keywords:Bladder cancer, curcumin, natural compound, inflammation, autophagy, angiogenesis, analog, delivery system, apoptosis, oxidative
stress, cancer therapy, urology.`
Abstract:Bladder cancer, a life-threatening serious disease, is responsible for thousands of cancer-associated
deaths worldwide. Similar to other malignancies, standard treatments of bladder cancer, such as Chemoradiotherapy,
are not efficient enough in the affected patients. It means that, according to recent reports in the
case of life quality as well as the survival time of bladder cancer patients, there is a critical requirement for
exploring effective treatments. Recently, numerous investigations have been carried out to search for appropriate
complementary treatments or adjuvants for bladder cancer therapy. Curcumin, a phenolic component with a
wide spectrum of biological activities, has recently been introduced as a potential anti-cancer agent. It has been
shown that this agent exerts its therapeutic effects via targeting a wide range of cellular and molecular pathways
involved in bladder cancer. Herein, the current data on curcumin therapy for bladder cancer are summarized.
