Phthalazinone Scaffold: Emerging Tool in the Development of Target Based Novel Anticancer Agents

Author(s): Jyoti Singh*, Amruta Suryan, Sandeep Kumar, Shweta Sharma

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 20 , Issue 18 , 2020

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Graphical Abstract:


Phthalazinones are important nitrogen-rich heterocyclic compounds which have been a topic of considerable medicinal interest because of their diversified pharmacological activities. This versatile scaffold forms a common structural feature for many bioactive compounds, which leads to the design and development of novel anticancer drugs with fruitful results. The current review article discusses the progressive development of novel phthalazinone analogues that are targets for various receptors such as PARP, EGFR, VEGFR-2, Aurora kinase, Proteasome, Hedgehog pathway, DNA topoisomerase and P-glycoprotein. It describes mechanistic insights into the anticancer properties of phthalazinone derivatives and also highlights various simple and economical techniques for the synthesis of phthalazinones.

Keywords: Cancer, phthalazinone, PARP inhibitor, VEGFR and EGFR inhibitors, aurora kinase inhibitors, proteasome inhibitors, hedgehog pathway inhibitors, DNA topoisomerases inhibitors, P-glycoprotein inhibitors.

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Article Details

Year: 2020
Published on: 23 November, 2020
Page: [2228 - 2245]
Pages: 18
DOI: 10.2174/1871520620666200807220146
Price: $65

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