A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents

Author(s): Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Eleni A. Rekka*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 1 , 2021

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Vitamin E, essential for human health, is widely used worldwide for therapeutic or dietary reasons. The differences in the metabolism and excretion of the multiple vitamin E forms are presented in this review. The important steps that influence the kinetics of each form and the distribution and processing of vitamin E forms by the liver are considered. The antioxidant as well as non-antioxidant properties of vitamin E forms are discussed. Finally, synthetic tocopherol and trolox derivatives, based on the design of multitarget directed compounds, are reviewed. It is demonstrated that selected derivatization of vitamin E or trolox structures can produce improved antioxidants, agents against cancer, cardiovascular and neurodegenerative disorders.

Keywords: Vitamin E, tocopherols, tocotrienols, metabolism, transport, antioxidants, trolox, synthetic analogues.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 21
ISSUE: 1
Year: 2021
Published on: 29 January, 2021
Page: [10 - 22]
Pages: 13
DOI: 10.2174/1389557520666200807132617
Price: $65

Article Metrics

PDF: 10