Development of novel metallodrugs with pharmacological profile plays a significant role in
modern medicinal chemistry and drug design. Metal complexes have shown remarkable clinical results
in current cancer therapy. Gold complexes have attained attention due to their high antiproliferative
potential. Gold-based drugs are used for the treatment of rheumatoid arthritis. Gold-containing compounds
with selective and specific targets are capable to assuage the symptoms of a range of human
diseases. Gold (I) species with labile ligands (such as Cl in TEPAuCl) interact with isolated DNA;
therefore, this biomolecule has been considered as a target for gold drugs. Gold (I) has a high affinity
towards sulfur and selenium. Due to this, gold (I) drugs readily interact with cysteine or selenocysteine
residue of the enzyme to form protein-gold(I) thiolate or protein-gold (I) selenolate complexes that
lead to inhibition of the enzyme activity. Au(III) compounds due to their square-planner geometriesthe
same as found in cisplatin, represent a good source for the development of anti-tumor agents. This
article aims to review the most important applications of gold products in the treatment of human colon
cancer and to analyze the complex interplay between gold and the human body.
Keywords: Medicinal application of gold, phosphane complexes, auranofin, NHCs, colon cancer, cancer therapy.
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